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Julie Fagan Julie Fagan
Associate Research Professor
 Animal Sciences
Bartlett 109
84 Lipman Drive
New Brunswick, NJ 08901
Phone: 732-932-8354
Fax: 732-932-6996
Email: fagan@aesop.rutgers.edu
Website: www.anisci.rutgers.edu/faculty/fagan/fagan.html

Expertise Summary
  My primary research focus is on the enzymes that break down proteins (proteases) and compounds that inhibit specific proteases (protease inhibitors) and the mechanisms by which they regulate the many biological and pathological processes (blood clotting, digestion, growth, metabolism, tissue remodeling, infection, cancer). Interests include: The role of proteases and their inhibitors in health and disease and in the intracellular removal of normal and abnormal proteins in physiological and pathological states Effect of antioxidants, reactive oxygen species, and environmental factors in heart disease, cancer, infection, and other pathological conditions in animals and humans and on the survival of animal species Utilizing proteases and their inhibitors as targets for the development of new drug treatments

Research Projects
  • The effect of diet and metabolic disrupters on brain proteins and peptides: A proteomic approach to the regulation of food intake neuropeptides

    • Selected Publications
    Activation of the multicatalytic endopeptidase by oxidants. Effects on enzyme structure.
      Journal: Biochemistry
     Authors: Strack PR, Waxman L, Fagan, JM
    Volume: 35    Pages: 1742-1749
    Date Published: 1996
    L-Arginine reduces right heart hypertrophy in hypoxia-induced pulmonary hypertension.
      Journal: Biochem.Biophys Res Commun
     Authors: Fagan JM, Rex SE, Hayes-Licitra SA, Waxman L
    Volume: 254    Pages: 100-103
    Date Published: 1999
    Postranslational modifications of cardiac and skeletal muscle proteins by reactive oxygen species after burn injury in the rat.
      Journal: Annals of Surgery
     Authors: Fagan JM, Ganguly M, Stockman H, Ferland LH, Toner M
    Volume: 229    Pages: 106-114
    Date Published: 1999

     

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